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بررسی اثرات افزودن همزمان آلفا توکوفرول (ویتامین E) و کربن نانوتیوب‌های چند دیواره عامل دار (MWCNT) بر خواص مکانیکی و زیست سازگاری ماتریس پلیمری پلی‌اتیلن با وزن مولکولی بسیار بالا (UHMWPE) باهدف کاربرد در تعویض مفاصل | ||
| زیست شناسی کاربردی | ||
| مقاله 6، دوره 36، شماره 2 - شماره پیاپی 76، شهریور 1402، صفحه 95-112 اصل مقاله (1.56 M) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22051/jab.2023.42305.1529 | ||
| نویسندگان | ||
| محسن فکوری1؛ محمد تقی خراسانی* 2؛ مهدی کمالی دولت آبادی3 | ||
| 11-دانشجوی دکتری، گروه بیومتریال، پژوهشکده فناوری نانو و مواد پیشرفته، پژوهشگاه مواد و انرژی، مشکین‌دشت، کرج، ایران 2-گروه مهندسی پزشکی (بیومتریال)، دانشکده فنی مهندسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران | ||
| 2دانشیار، گروه پلیمرهای زیست‌سازگار و پلیمرهای طبیعی، پژوهشکده علوم پلیمر، پژوهشگاه پلیمر و پتروشیمی ایران، تهران، ایران | ||
| 3استادیار، گروه مهندسی نساجی، دانشکده فنی مهندسی، واحد علوم و تحقیقات، دانشگاه آزاد اسلامی، تهران، ایران | ||
| چکیده | ||
| مقدمه: پلی‌اتیلن با وزن مولکولی فوق‌العاده بالا (UHMWPE) به علت خواص فیزیکی و شیمیایی فوق‌العاده، طی سه دهه‌ی اخیر به‌عنوان ماده انتخابی در پروتزهای تعویض مفاصل استفاده شده است. بااین‌وجود، سایش و اکسیداسیون این پلیمر در درازمدت منجر به استئولیز (تخریب استخوان) و محدودکردن طول عمر این پروتز می‌شود. یکی از روش‌های موثر جهت جلوگیری از اکسیداسیون، استفاده از α-توکوفرول در ماتریس UHMWPE است. اما حضور این افزودنی به تنهایی باعث بهبود عملکرد مکانیکی UHMWPE نمی شود. از طرف دیگر استفاده از نانوتیوب‌های کربنی چند دیواره (MWCNTs) به دلیل خواص استثنایی مانند مدول الاستیک و نسبت سطح به حجم بالا،نشان داده شده است که می توانند موجب بهبود خواص مکانیکی شوند. با این وجود پیدا کردن مقادیر بهینه استفاده از MWCNTs و ویتامین E به صورت همزمان جهت بهبود خواص مکانیکی این پلیمر بسیار حیاتی و مهم است.روش‌ها: در این پژوهش جهت بررسی و مقایسة تاثیر نانوتیوب‌های کربنی بر خواص کامپوزیت UHMWPE حاوی ویتامین E، دو کامپوزیت، یکی حاوی 0.2 درصد وزنی ویتامین E و دیگری حاوی 0.25 درصد وزنی ویتامین E به همراه 0.5 درصد وزنی MWCNT تولید شدند. نتیجه و بحث: طیف‌سنجی مادون‌قرمز تبدیل فوریه (FTIR) افزایش پیک‌های مشخصه ی کامپوزیت PE-E/CNT را نسبت به کامپوزیت PE-E گزارش داد. گرماسنجی روبشی تفاضلی (DSC) افزایش حدود 7 درصدی بلورینگی را در کامپوزیت PE-E/CNT گزارش داد. آنالیز حرارتی مکانیکی دینامیکی (DMTA) نیز بهبود خواص الاستیک را در کامپوزیت PE-E/CNT نسبت به کامپوزیت حاوی ویتامین E نشان داد. | ||
| کلیدواژه‌ها | ||
| : کامپوزیت UHMWPE/Vitamin E؛ کامپوزیت زمینه UHMWPE؛ کامپوزیت UHMWPE/Vitamin E/MWCNT؛ مفاصل مصنوعی | ||
| عنوان مقاله [English] | ||
| Investigation on the effects of simultaneous adding of α -tocopherol (vitamin E) and Multi-walled carbon nanotubes (MWCNT) on the mechanical properties and biocompatibility of the ultra-high molecular weight polyethylene polymer matrix (UHMWPE) | ||
| نویسندگان [English] | ||
| Mohsen Fackori1؛ Mohammad taghi Khorassani2؛ Mehdi Kamali Dolatabadi3 | ||
| 11.PhD student, Department of Biomaterials, Nanotechnology and Advanced Materials Research Institute, Materials and Energy Research Institute, Meshkindasht, Karaj, Iran 2.Department of Medical Engineering (Biomaterials), Faculty of Engineering, Science and Research Unit, Islamic Azad University, Tehran, Iran | ||
| 2ssociate Professor, Biocompatible Polymers and Natural Polymers Department, Polymer Science Research Institute, Iran Polymer and Petrochemical Research Institute, Tehran, Iran | ||
| 3Assistant Professor, Department of Textile Engineering, Faculty of Engineering, Science and Research Unit, Islamic Azad University, Tehran, Iran | ||
| چکیده [English] | ||
| Introduction: Ultra high molecular weight polyethylene (UHMWPE) has been used as the material of choice in joint replacement prosthesis for the last three decades due to its excellent physical and chemical properties. However, UHMWPE’s wear and oxidation in the long term leads to osteolysis and limits the lifespan of this polymer. One of the effective methods to prevent oxidation is presents of α-tocopherol in UHMWPE matrix. But the presence of this additive alone does not improve the mechanical performance of UHMWPE. On the other hand, the use of multi-walled carbon nanotubes (MWCNTs) has been shown to improve mechanical properties due to their exceptional properties such as elastic modulus and high surface-to-volume ratio. However, finding the optimal concentration of MWCNTs and vitamin E to improve the mechanical properties of this polymer is very vital and important. methods: In this research, to investigate and compare the effects of carbon nanotubes on the properties of UHMWPE/vitamin E composite, two composites were produced, one containing 0.2% by weight of vitamin E and the other containing 0.25% by weight of vitamin E along with 0.5% by weight of MWCNT. Results and Conclusion: Fourier transform infrared spectroscopy (FTIR) reported an increase in the characteristic peaks of PE-E/CNT composite compared to PE-E composite. Differential scanning calorimetry (DSC) reported about 7% increase in crystallinity in PE-E/CNT composite. Dynamic thermos mechanical analysis (DMTA) also showed improved elastic properties in the PE-E/CNT composite compared to the composite containing vitamin E. Finally, | ||
| کلیدواژه‌ها [English] | ||
| Artificial joint replacement, UHMWPE/Vitamin E composite, UHMWPE base composite, UHMWPE/Vitamin E/MWCNT composite | ||
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