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اثر چهار هفته ورزش و مکمل دهی اولئوروپین بر رفتارهای اضطراب و افسردگی در مدل حیوانی بیماری پارکینسون | ||
| زیست شناسی کاربردی | ||
| دوره 35، شماره 1 - شماره پیاپی 71، خرداد 1401، صفحه 180-195 اصل مقاله (693.96 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22051/jab.2021.36815.1432 | ||
| نویسندگان | ||
| معصومه مکوندی چشمه چنار1؛ عبدالحسن دولاح* 2؛ مریم رفیعی راد3 | ||
| 1کارشناس ارشد گروه آموزشی تربیت بدنی و علوم ورزشی، دانشکده علوم انسانی، واحد اهواز، دانشگاه آزاد اسلامی، اهواز، ایران | ||
| 2استادیار گروه زیست شناسی، دانشکده علوم پایه، واحد اهواز، دانشگاه آزاد اسلامی، اهواز، ایران | ||
| 3استادیار گروه زیست شناسی، دانشکده علوم پایه، واحد ایذه، دانشگاه آزاد اسلامی، ایذه، ایران | ||
| چکیده | ||
| بیماری پارکینسون تحلیل نورون های دوپامینی در ساختمان متراکم جسم سیاه و دیگر نواحی ساقه مغز است. اضطراب و افسردگی در پارکینسون شایع است. مطالعه ﺣﺎﺿﺮ با هدف ﺑﺮرﺳﻲ اﺛﺮ ماده اولئوروپین و ورزش بر اضطراب و افسردگی در ﻣﺪل حیوانی ﺑﻴﻤﺎری ﭘﺎرﻛﻴﻨﺴﻮن انجام شد در این مطالعه تجربی، 40 سر موش صحرایی به پنج گروه کنترل، پارکینسونی (6-هیدروکسی دوپامین به ناحیه جسم مخطط به‌صورت یک‌طرفه)، ورزش (پنج جلسه در هفته و هر جلسه 30 دقیقه)، دریافت کننده اولئوروپین به مدت 4 هفته (روزانه 20 میلی گرم به ازای هر کیلوگرم وزن بدن) و توام تمرین شنا و اولئوروپین تقسیم شدند. برای ارزیابی اضطراب از تست ماز به علاوه‌ای شکل مرتفع و برای سنجش افسردگی از تست جعبه باز انجام گرفت. از آزمون آماری تحلیل واریانس یک‌طرفه و تعقیبی توکی جهت تعیین تفاوت بین گروه‌ها استفاده شد. نتایج نشان دادند که مصرف اولئوروپین همراه با ورزش، مدت زمان حضور حیوان مدل پارکینسونی را در بازوها ی باز ماز بعـلاوه ای بـه طـور معنـی داری افـزایش می دهد (05/0P<). همچنین، مصرف اولئوروپین همراه با ورزش در تست جعبه باز، تعداد عبور حیوان از مربع مرکزی، بـه طـور معنـی داری افـزایش و تعداد عبور از مربع‌های حاشیه و تعداد بالا بردن دست ها بـه طـور معنـی داری کاهش می دهد (05/0P<). نتایج این مطالعه نشان داد که ورزش توام با مصرف اولئوروپین می تواند با تاثیر آنتی اکسیدانی خود سبب بهبود رفتارهای اضطرابی و افسردگی در رت های پارکینسونی شود. | ||
| کلیدواژه‌ها | ||
| اضطراب؛ افسردگی؛ اولئوروپین؛ پارکینسون؛ ورزش | ||
| عنوان مقاله [English] | ||
| The effect of four weeks of exercise and oleuropein supplementation on anxiety and depression behaviors in an animal model of Parkinson's disease | ||
| نویسندگان [English] | ||
| Somayeh Ghasemzadeh Dehkordi1؛ Abdolhassan Doulah2؛ Maryam Rafieirad3 | ||
| 1Physical Education and Sport Sciences Department, Faculty of Human, Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran | ||
| 2Biology Department, Faculty of Basic Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran | ||
| 3Biology Department, Faculty of Basic Sciences, Ahvaz Branch, Islamic Azad University, Ahvaz, Iran | ||
| چکیده [English] | ||
| Parkinson's disease is a destroyer of dopamine neurons in the dense structure of the substantia nigra and other areas of the brainstem. Anxiety and depression are common in Parkinson's. The aim of this study was to investigate the effect of oleuropein and exercise on anxiety and depression in animal models of Parkinson's disease. In this experimental study, 40 rats were divided into five groups: control, Parkinson's (6-hydroxy dopamine to the striatum area unilaterally), swimming practice (five sessions per week and 30 minutes each session), oleuropein recipient for 4 weeks (20 mg per kilogram of body weight per day) and combined with swimming practice and oleuropein. To assess anxiety, the elevated plus maze test was performed and to assess depression, the open box test was performed. One-way ANOVA and Tukey's post hoc test were used to determine the differences between the groups. The results showed that the use of oleuropein with exercise significantly increased the duration of Parkinson's model animal in the Plus open maze arms (P<0.05). Also, the use of oleuropein with exercise in open feild box testing significantly increases the number of animals crossing the central square and significantly reduces the number of crossings of marginal squares and the number of hands raised (P<0.05). The results of this study showed that exercise combined with oleuropein consumption can improve anxiety and depression behaviors in Parkinson's rats with its antioxidant effect. | ||
| کلیدواژه‌ها [English] | ||
| anxiety, depression, oleuropein, Parkinson', s, Exercise | ||
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| مراجع | ||
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Anderson, E. and Shivakumar, G. (2013) Effects of exercise and physical activity on anxiety. Front Psychiatry. 4 (27). Asci, F.H. (2003) The Effects of physical fitness training on trait anxiety and physical self-concept of female university student. J Psychol Sport Exercise, 4(2): 255-64. Aytul, K.K. (2010) Antimicrobial and antioxidant activities of olive leaf extract and its food applications. Izmir institute of technology. Available at: http://library.iyte.edu.tr/tezler/master/biyoteknoloji/T000831.pdf. Bourin, M., Chenu F., Prica C. and Hascoet M. (2009) Augmentation effect of combination therapy of aripiprazole and antidepressants on forced swimming test in mice . Psychopharmacol., 206: 97–107. Bueno, C.H., Zangrossi, Jr H. and Viana, M.B. (2005) The inactivation of the basolateral nucleus of the rat amygdala has an anxiolytic effect in the elevated T-maze and light/dark transition tests. Braz J Med Biol Res, 38(11):1697-1701. Degroot, A., Kashluba, S. and Treit, D. (2001) Septal GABAergic and hippocampal cholinergic systems modulate anxiety in the plus-maze and shock-probe tests. Pharmacol. Bioch. Behave., 69:391-9. Dekanski, D., Selakovic, V., Piperski, V., Radulovic, Z., Korenic, A., and Radenovic, L. (2011) Protective effect of olive leaf extract on hippocampal injury induced by transient global cerebral ischemia and reperfusion in Mongolian gerbils. Phytomedicine, 18(13), 1137-1143. Dexter David, T. and Jenner, P. (2013) Parkinson disease: from pathology to molecular disease mechanisms. Free Radical Biology and Medicine, 62, 132-144. Dissanayaka, N.N., Sellbach, A., Matheson, S., O'Sullivan, J.D., Silburn, P.A., Byrne, G.J., Marsh, R. and Mellik, G.D. (2010) Anxiety disorders in Parkinson's disease: prevalence and risk factors. Mov Disord, 25(7): 838-45. Farzin, D., Zarghami, M. and Khalaj, L. (2005) Evaluation of antidepressant activities of Rose oil and Geranium oil in the mouse forced swim test. J Babol Univ Med Sci., 7(1): 7-13. Grohol, J.M. (2006) Depression in women, seniors and children. [ebook]. Available from: http://psychcentral.com/lib/2006/the-causes-of-depression. Happe, S., Schrodl, B., Faltl, M., Muller, C., Auff, E. and Zeitlhofer, J. (2001) Sleep disorders and depression in patients with Parkinson's disease. Acta Neurol Scand., 104(5): 275-80. Hasty, S. (2000) Gender studies: obesity Increases risks of depression & suicide in women,decreases risks in womans health weekly. Available from. http://www.newsrx.com/newsletters/Women. Heidarya, A. Emami, A. Eskandaripour, S. Saiah, A., Hamidi, S. and Shahbazi, M. (2011) Effects of aerobic exercise on anxiety. Procedia Social Behavioral Science, 30: 2497-2498. Herring, M.P. Jacob, M.L. Suveg, C. and O’Connor, P.J. (2011) Effects of short-term exercise training on signs and symptoms of generalized anxiety disorder. Mental Health and Physical Activity, 4: 71-77. Jafari, F., Doulah, A. and Rafieirad, M. (2020) Effect of oleuropein and swimming practice on motor disorder induced by 6-hydroxydopamine toxin in mature male rats.JBRMS. 7 (1) :50-60 Ji, L.L. (1993) Antioxidant enzyme response to exercise and training in the skeletal muscle. Oxidative Stress in skeletal muscle. 25(2): 225–31. Lockyer, S., Corona, G., Yaqoob, P., Spencer, J.P. and Rowland, I. (2015) Secoiridoids delivered as olive leaf extract induce acute improvements in human vascular function and reduction of an inflammatory cytokine: a randomised, double-blind, placebo-controlled, cross-over trial. Br JNutr. 8:1-9. Mahmoudi, R., Rafieirad, M. and Goudarzi, S. (2018). Effect of Hydroalcoholic Extract of Ferulago angulata (Schlecht) Boiss on Motor and Memory Disorders in Animal Model of Parkinson Disease. Qom Univ Med Sci J. 12(8): 36-47. Nagatsu, T. (2002) Amine-related neurotoxins in Parkinson's disease: past, present, and future. Neurotoxicology and Teratology. 24(5); 565-9. Obied, H.K., Prenzler, P.D., Omar, S.H., Ismael, R., Servili, M. and Esposto, S. (2012) Pharmacology of olive biophenols, Chapter 6. In book: Advances in Molecular Toxicology. Elsevier. p.195. Omar, S.H. (2010) Oleuropein in olive and its pharmacological effects. Sci Pharm. 78(2): 133-54. Pietrelli, A., Lopez-Costa, J., Goni, R., Brusco, A. and Basso, N. (2012) Aerobic exercise prevents age-dependent cognitive decline and reduces anxiety-related behaviors in middle-aged and old rats. Neuroscience. 202: 252-266. Pourkhodadad, S., Alirezaei, M., moghadasi, m., Delfan, B., Ahmadvand, H., Karami, M., et al. (2016). The effect of oleuropein on passive avoidance memory in colchicine-induced rat model of Alzheimer’s disease. Daneshvar Medicine, 23(124); 1-8. Rafieirad, M. and Abbaszadeh, H. (2017) Pomegranate seed extract reduces ischemia induced anxiety in male rats. J Herbmed Pharmacol. 6(2):85-89. Sadok, B.J. (2004) Abstract of psychiatry. Trans Rafiei H, Sobhanian Kh. Tehran: Arjmand; [Persian] Strohle, A. (2009) Physical activity, exercise, depression and anxiety disorders. J. Neural Transm. 116: 777-784. Smith, L.L. and Elliott, C.H. (2003) Demystifying and defeating depression. [ebook]. Wiley. p. 9-20. Sonei, A., Hajrasouliha, S.h., Hadipour Jahromy, M., Movaseghi, S.h. and Sharifi, N.Z. (2018) Effect of Aqueous Extra Ctfruito frhus Coriaria on Reducing Anxiety and Pain in Mice. Qjaphd. 44: 35-45. Soltani Shall, R., Aghamohammadian Sharbaf, H. and Ghanaei chamanabad, A. (2013) Effect of exercise on general health, quality of sleep and quality of life in Ferdowsi University of Mashhad students. JQUMS. 17(4): 39- 46. [in Persian] Soltaniyan, M.A. and Aminbeidokhti, A.A. (2009) The role of sport on job burnout of employees. J Semnan Unive Med Sci. 10(4): 281-6. [in Persian] Savica, R., Rocca, W.A. and Ahlskog, J.E. (2010) When does Parkinson disease start? Archneurosci. 67(7): 798-801. Schuch, F.B., Vasconcelos-Moreno, M.P., Borowsky, C. and Fleck, M.P. (2011) Exercise and severe depression: preliminary results of an add-on study. J Affect Disord. 133(3): 615-8. Shah, G., Shiri, R., Dhabiliya, F., Nagpal, N. and Mann, A.S. (2010) Anti-anxiety activity of cymbopogon citratus (dc.) stapf leaves extracts on the elevated plus-maze model of anxiety in mice. Pharmaco J. 2(15): 45-50. Sharjerdi, S.H., Shondi, N. and Sheikh Hoseini, R. (2010) The effect of strength and endurance training on blood glucose control, quality of life and mental health in women with type 2 diabetes. IJDLD. 9(1): 35- 44. [in Persian] Shrivastava, P., Vaibhav, K., Tabassum, R., Khan, A., Ishrat, T., Khan, M.M., Ahmad, A., Islam, F. Safhi, M.M. and Islam, F. (2013) Anti-apoptotic and anti-inflammatory effect of piperine on 6-OHDA induced Parkinson's rat model. J Nutr Biochem. 24(4): 680-7. Tadaiesky, M.T., Dombrowski, P.A., Figueiredo, C.P., Cargnin-Ferreira, E., Da Cunha, C. and Takahashi, R.N. (2008) Emotional, cognitive and neurochemical alterations in a premotor stage model of Parkinson's disease. Neuroscience. 156(4): 830-40. Torabi, M., Kesmati, M., Eshagh Harooni, H. and Najafzadeh Varzi, H. (2014) The effect of local and intraperitoneal administration of opioid receptors modulating agents on anxiolytic properties of nano and conventional ZnO in male rats. Cell J. 16: 1, 37-61. Vauzour, D., Rodriguez-Mateos, A., Corona, G., Oruna-Concha, M.J. and Spencer, J.P. (2010) Polyphenols and human health: prevention of disease and mechanisms of action. Nutrients. 2(11): 1106-31. Yoon, M.C., Shin, M.S., Kim, T.S., Kim, B.K., Ko, I.G., Sung, Y.H., Kim, S.E., Lee, H.H., Kim, Y.P. and Kim, C.J. (2007) Treadmill exercise alleviates short-term memory impairment in 6-hydroxydopamine-induced Parkinson's rats. Neurosci Lett. 423(1): 12-7.9. | ||
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