استخراج و خالص سازی ماده موثره دارویی γ-Pyrones (خلین و ویسناژین) از گیاه Ammi Visnaga L.

 Abdel-Fattah, A., Aboul-Enein, M. N., Wassel, G., El-Menshawi, B. S. 1983. Preliminary report on the therapeutic effect of khellin in psoriasis. Dermatologica. 167, 109–110.

Abdel-Fattah, A., Aboul-Enein, M. N., Wassel, G. M., El-Menshawi, B. S. 1982. An approach to the treatment of vitiligo by khellin. Dermatologica. 165, 136–140. 

Abdul-Jalil, T. Z., Saour, K. and Nasser, A. A. 2010. Phytochemical Study of some Flavonoids Present in the Fruits of Two Ammi L. Species Wildly Grown in Iraq, Iragi Journal of Pharmaceutical Sciences, 19(1): 48-57.

Ali, H., Ahmad, H., Marwat, K.B., Yousaf, M., Gul, B. and Khan, I.  2012. Trade potential and conservation issues of medicinal plants in District Swat, Pakistan. Pakistan Journal Botanical, 44: 1905-1912.

Alqasoumi, S. I., Alam, P., Anwer, M. K. and Abdel-Kader, M. S. 2014. QualItative and quantitative analysis of khellin in Ammi visnaga fruits and pharmaceutical preparations using HPTLC and HPLC. Journal of Liquid Chromatography & Related Technologies, 37: 61-72.

Al-Snafi, A.E. 2016. A Review of Medicinal Plants with Broncho-Dilatory Effect-Part 1. Scholars Academic Journal Pharmacy, 5: 297–304.

Anonymous. 2007. WHO monographs on selected medicinal plants, 3: 23-32.

Ashour, A., El Sharkawy, S., Amer, M., Abdelbar, F., Kondo, R. 2013. Melanin Biosynthesis Inhibitory Activity of Compounds Isolated from Unused Parts of Ammi visinaga. Journal Cosmetic Dermatology Scientific Application, 3: 40–43.

Badr, J. M., Hadad, G. M., Nahriry, K. and Hassanean, H. A. 2015. Validated HPLC method for simultaneous estimation of khellol glucoside, khellin and visnagin in Ammi visnaga L. fruits and pharmaceutical preparations. Natural Product Research, 29(7): 593-601.

Bailey, S. D., Geary, P. A., De-Wald, A. E. 1951. Khellin. Part I. Ultraviolet, Infrared, and Polarographic Studies on Three Principles Isolated from Ammi visnaga Lam. Journal of The American Pharmaceutical Association. XL 6: 280-286.

Barakat, M. Z., Badran, N. 1951. New tests for the identification of khelin, visnagin and khellol-glucoside. Journal of Pharmacy and Pharmacology, 3: 576-580.

Beltagy, A. M. and Beltagy, D. M. 2015. Chemical composition of Ammi visnaga L. and New Cytotoxic Activity of its Constituents Khellin and Visnagin. Journal of Pharmceutical Sciences and Research, 7(6): 285-291.

Bhagavathula, A. S., Al‑Khatib, A. J. M., Elnour, A. A., Al-Kalbani, N. M. S. and Shehab, A. 2015. Ammi Visnaga in treatment of urolithiasis and hypertriglyceridemia. Pharmacognosy Research, 7(4): 397-400.

Bishr, M., El Degwy, M., Amin, M., Salama, O. 2016. HPLC Simultaneous Determination of Khellin and Visnagin in Ammi visnaga L. Fruits. Journal Pharmaceutical and Biological Sciences, 11: 110–115.

Buriak, V.P., Kurinna, N.V. 1971. Spectrophotometric determination of kellin and santonin. Farmatsevtychnyi Zhurnal, 26: 39–42.

Chen, M., Stohs S. J., Staba, E. J. 1969. The biosynthesis of radioactive khellin and visnagin from C¹⁴-acetate by Ammi visnaga plants. PIanta Medicine, 17(4): 319-327.

Chevallier, A. 1996. The Encyclopedia of Medicinal Plants; Dorling Kindersley: London, UK.

Dalila, B., Smahane, B., Abderrahman, A., Mohamed, G., Latifa, E. 2014. Ethnopharmacological Study of Antidiabetic medicinal plants used in the Middle-Atlas region of Morocco (Sefrou region). International Journal Pharmaceutical Research and Health Sciences, 2: 75–79.

De Leeuw, J. d., Assen, Y.J., Beek, N. V., Bjerring, P. and Neumann H. A. M. 2011. Treatment of vitiligo with khellin liposomes, ultraviolet light and blister roof transplantation. Journal of the European Academy of Dermatology and Venereology, 25: 74–81.

Duarte, J., Torres, A.I., Zarzuelo, A. 2000. Cardiovascular effects of visnagin on rats, Planta Medica, 66(1): 35-39.

El-Domiaty M., M. 1992. Improved high-performance liquid chromatographic determination of khellin and visnagin in Ammi visnaga fruits and pharmaceutical formulations. Journal Pharmaceutical Sciences, 81(5): 475– 478.

Elgamal, M.H.A., Shalaby, N.M.M., El-Hagrassy, A.M., Toth, G., Simon, A., Duddeck, H. 1998. A further contribution to some gamma-pyrone constituents of Ammi visnaga. Fitoterapia, 69: 549–550.

Ellenbogen, w. C., Rump, E. S., Geary, P. A., Burke, M. 1951. Kehllin. Part II. Methods for the determination of two principles isolated from Ammi visnaga Lam. Journal of The American Pharmaceutical Association, XL (6): 287-290.

El-Shibini, H. A. M., Saleh, A. M., Motawi, M. M. 1969. Stability of khellin. Pharmazie, 24(11): 687-691.

Fahmy, I. R., Badran, N., Messeid, M. F. 1949. A photoelectric colorimetric method for the estimation of khellin. Journal of Pharmacy and Pharmacology, 1: 529-534.

Farnsworth, N.R., Krause, E.C., Bolton, J.L., Pauli, G.F., van Breemen, R.B., Graham, J.G. 2008. From plant to clinical use. The University of Illinois at Chicago/National Institutes of Health Center for Botanical Dietary Supplements Research for Women’s Health. American Journal Clinical Nutrition, 87: 504S–508S.

Feirouz, B., Salima, K.  2014. Antibacterial activity and chemical composition of Ammi visnaga l. Essential oil collected from Boumerdes (Algeria) during three periods of the plant growth. Journal of Essential Oil Bearing Plants, 17: 1317–1328.

Franchi, G. G., Bovalini, L., Martelli, P., Ferri, S., SbardellatiI, E. 1985. High performance liquid chromatography analysis of the furanochromones khellin and visnagin in various organs of Ammi visnaga (L.) Lam. At different developmental stages. Journal of Ethnopharmacology, 14: 203-212.

Ghareeb, A.M., Zedan, T.H., Gharb, L.A. 2011. Antibacterial and antifungal activities of Ammi visnaga extracts against pathogenic microorganisms. Iraqi Journal of Science, 52: 30–36.

Hashim, S., Jan, A., Marwat, K. B. and Khan, M. A. 2014. Phytochemistry and medicinal properties of Ammi Visnaga (Apiacae). Pakistan Journal Botanical, 46(3): 861-867.

Jaradat, N.A., Zaid, A., Al-Ramahi, R., Alqub, M.A., Hussein, F., Hamdan, Z., Mustafa, M.; Qneibi, M., Ali, I. 2017. Ethnopharmacological survey of medicinal plants practiced by traditional healers and herbalists for treatment of some urological diseases in the West Bank/Palestine. BMC Complementary and Alternative Medicine, 17: 255.

Jouad, H., Maghrani, M., Eddouks, M. 2002. Hypoglycemic effect of aqueous extract of Ammi visnaga in normal and streptozotocin-induced diabetic rats, Journal of Herbal Pharmacotherapy, 2(4): 19-29.

Kamal, A., Khan, W., Ahmad, S., Ahmad, F. J. and Saleem, K. 2015. Development and validation of high‑performance liquid chromatography and high‑performance thin‑layer chromatography methods for the quantification of khellin in Ammi visnaga seed. Journal of Pharmacy and Bioallied Sciences, 7(4): 308-313.

Karawya, M. S., EL-Kiey, M. A., Sina, A. and Nourf, G. 1970. Simultaneous TLC Separation of Khellin and Visnagin and Their Assay in Ammi visnaga Fruits, Extracts, and Formulations. Journal of Pharmaceutical Sciences, 59(7): 1025-1027.

Khan, Z.A., Assiri, A.M., Al-Afghani, H.M., Maghrabi, T.M. 2001. Inhibition of oxalate nephrolithiasis with Ammi visnaga (AI-Khillah), International Urology Nephrology, 33(4): 605-608.

Kwon, M.S., Lee, J.K., Park, S.H., Sim, Y.B., Jung, J.S and Won, M.H. 2010. Neuroprotective effect of visnagin on kainic acid-induced neuronal cell death in the mice Hippocampus, Korean Journal Physiology Pharmacology, 14: 257-263.

Lee, J.K., Jung, J.S., Park, S.H., Sim, Y.B., Kim, S.M. and Ha, T.S. 2010. Anti-inflammatory effect of visnagin in lipopolysaccharide-stimulated BV-2 microglial cells, Archives of Pharmacal Research, 33: 1843-1850.

Martelli, P., Bovalin, L. 1984. Rapid separation and quantitative determination of khellin and visnagin in Ammi wisnaga (L.) Lam. fruits by high-performance liquid chromatography. Journal of Chromatography, 301: 297-302.

Marwat, K.B., Hashim S. and Ali, H. 2010. Weed management: A case study from North West Pakistan. Pakistan Journal Botanical, 42: 341-353.

Mesbah, M., K. 1992. Determination of khellin and visnagin in Ammi visnaga fruits and in renal teas by high-performance liquid chromatography. Egyptian Journal of Pharmaceutical Sciences, 33: 897–904.

Miara, M., Bendif, H., Rebbas, K., Rabah, B., Hammou, M., Maggi, F. 2019. Medicinal plants and their traditional uses in the highland region of Bordj Bou Arreridj (Northeast Algeria). Journal of Herbal Medicine, 16: 100262.

Moubasher, R., Barakat, M.Z. 1950. Oxonium salts of khelin. Journal of American Chemical Society, 72: 2870.

Nirumand, M.C., Hajialyani, M., Rahimi, R., Farzaei, M.H., Zingue, S., Nabavi, S.M., Bishayee, A. 2018. Dietary Plants for the Prevention and Management of Kidney Stones: Preclinical and Clinical Evidence and Molecular Mechanisms. International Journal Molecular Sciences, 19: 765.

O’Neil, M. J. 2013. Merck Index. 15th Edition. An encyclopedia of chemicals, drugs and biologicals. Royal Society of Chemistry, Cambridge, UKISBN 9781849736701; 5189 & 9916.

Pavela, R. 2015. Acaricidal properties of extracts and major furanochromenes from the seeds of Ammi visnaga Linn. against Tetranychus urticae Koch. Industrial Crops and Products, 67: 108–113.

Rasooli, I., Taghizadeh, M., Astaneh, S.D.A., Rezaei, M.B., Jaimand, K. 2007. Phytobiological properties of Ammi visnaga L. and Lavandula angustifolia Mill. essential oils. International Journal of Essential Oil Therapeutics, 1: 72–78.

Satrani, B., A. Farah, M. Fechtal, M. Talbi and M.L. Boumari. 2004. Chemical composition and anti- microbial and antifungal activities of the essential oil of Ammi visnaga (L.) Lam. Acta Botanica Gallica, 151(1): 65-71.

Sellami, H.K., Napolitano, A., Masullo, M., Smiti, S., Piacente, S., Pizza, C. 2013. Influence of growing conditions on metabolite profile of Ammi visnaga umbels with special reference to bioactive furanochromones and pyranocoumarins. Phytochemistry, 95: 197–206.

Shinde, P. B. and Laddah, K. S. 2014. Development of new isolation technique and validated HPLC method development for khellin-A major constituent of Ammi visnaga Lam. fruits. Indian Journal of Nautral Products and Resources, 5(1): 40-43.

Travaini, M. L., Sosa, G. M., Ceccarelli, Eduardo A., Walter, H., Cantrell, C. L., Carrillo, N. J., Dayan, Franck E., Meepagala, K. M. and Duke, S. O. 2016. Khellin and Visnagin, Furanochromones from Ammi visnaga (L.) Lam., as Potential Bioherbicides, Journal of Agricultural and Food Chemistry, 64: 9475-9487.

Tripathi, Y., Pandey, A. 2017. Bioprospecting of Phytodiversity for New Therapeutic Products: Trends, Potential and Challenges. Organic and Medical Chemistry, 2: 1–7.

Vanachayangkul, P., Chow, N., Khan, S.R., Butterweck, V. 2011. Prevention of renal crystal deposition by an extract of Ammi visnaga L. and its constituent khellin and visnagin in hyperoxaluric rats, Urological. Research. 39: 189-195.

Wagner, H., Bladt. S. 1996. Coumarin drugs. Plant drug analysis. 125-147.

Wagner, H., Bladt. S., Zgalmski, E. M. 1984. Coumarin drugs. Plant drug analysis. 145-161.

World Health Organization. 2011. Quality control methods for herbal materials. Geneva, pp: 29, 35, 69-70.

World Health Orgaization. 1998. Quality control methods for medicinal Plant materials. Geneva, Switzerland. pp: 28-29, 33, 61-63.

Zargari, A. 1989. Medical plants, Vol. 2, 4th ed. Tehran, Tehran University Publications, No. 181012.