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Alipourfard, F., Shajiee, H., nazari-serenjeh, F., hojati, V., alirezaie, M. (2020). Effect of Betaine on memory dysfunction and Activity ofsuperoxide dismutase (SOD) enzyme in Alzheimer's model induced by intra-hippocampal Beta-Amyloid Protein Injection. Glory of Art (Jelve-y Honar) Alzahra Scientific Quarterly Journal, 33(2), 78-89. doi: 10.22051/jab.2020.30229.1349
Fatemeh Alipourfard; Hooman Shajiee; farzaneh nazari-serenjeh; vida hojati; Masoud alirezaie. "Effect of Betaine on memory dysfunction and Activity ofsuperoxide dismutase (SOD) enzyme in Alzheimer's model induced by intra-hippocampal Beta-Amyloid Protein Injection". Glory of Art (Jelve-y Honar) Alzahra Scientific Quarterly Journal, 33, 2, 2020, 78-89. doi: 10.22051/jab.2020.30229.1349
Alipourfard, F., Shajiee, H., nazari-serenjeh, F., hojati, V., alirezaie, M. (2020). 'Effect of Betaine on memory dysfunction and Activity ofsuperoxide dismutase (SOD) enzyme in Alzheimer's model induced by intra-hippocampal Beta-Amyloid Protein Injection', Glory of Art (Jelve-y Honar) Alzahra Scientific Quarterly Journal, 33(2), pp. 78-89. doi: 10.22051/jab.2020.30229.1349
Alipourfard, F., Shajiee, H., nazari-serenjeh, F., hojati, V., alirezaie, M. Effect of Betaine on memory dysfunction and Activity ofsuperoxide dismutase (SOD) enzyme in Alzheimer's model induced by intra-hippocampal Beta-Amyloid Protein Injection. Glory of Art (Jelve-y Honar) Alzahra Scientific Quarterly Journal, 2020; 33(2): 78-89. doi: 10.22051/jab.2020.30229.1349

Effect of Betaine on memory dysfunction and Activity ofsuperoxide dismutase (SOD) enzyme in Alzheimer's model induced by intra-hippocampal Beta-Amyloid Protein Injection

زیست شناسی کاربردی
Article 6, Volume 33, Issue 2 - Serial Number 64, September 2020, Pages 78-89    PDF (525.91 K)
Document Type: Research Paper
DOI: 10.22051/jab.2020.30229.1349
Authors
Fatemeh Alipourfard1; Hooman Shajiee* 2; farzaneh nazari-serenjeh3; vida hojati2; Masoud alirezaie4
1Ph.D. Student, Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
2Assistant Professor, Department of Biology, Damghan Branch, Islamic Azad University, Damghan, Iran
3Assistant Professor, Department of Biology, Payame Noor University (PNU), Tehran, Iran
4Associated Professor, Department of Biochemistery, Faculty of Dampezechki, Lorestan Univer sity , KHoramabad Iran
Abstract
Studies indicate that oxidative stress has important role in the pathogenesis of Alzheimer disease. Betaine has neuroprotective and antioxidant properties.  The purpose of this study was to investigate the effect of betaine on memory dysfunction induced by intra-hippocampal injection of amyloid beta and measurement of superoxide dismutase (SOD) activity. In this experimental study, animals were divided into 5 groups (n=8 in each group) including: control group, Alzheimer group and betaine (5, 10, and 15 mg/kg body weight + Aß) groups. Seven days after Aß injection memory was assessed by avoidant learning. The activity of antioxidant enzyme was measured via chemical methods. Data were analyzed by One-way ANOVA test. Results: The results showed in the Alzheimer's group, Aß impaired memory and reduced SOD activity in comparison with control group.  In contrast, betaine pretreatment significantly improved memory and increased SOD activity.This study shows that betaine as an antioxidant can improve memory by decreasing the oxidative stress.
Keywords
Alzheimer; Betaine; Passive avoidance learning; Superoxide dismutase
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