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اثر زیره سیاه بر فاکتورهای آنتی اکسیدانی و پارامترهای استرس اکسیداتیو در رت‌های مواجه شده با 1 و 2- دی متیل هیدرازین | ||
| زیست شناسی کاربردی | ||
| مقاله 4، دوره 32، شماره 4 - شماره پیاپی 62، اسفند 1398، صفحه 58-75 اصل مقاله (972.04 K) | ||
| نوع مقاله: مقاله پژوهشی | ||
| شناسه دیجیتال (DOI): 10.22051/jab.2020.4803 | ||
| نویسندگان | ||
| ابوالفضل دادخواه* 1؛ فائزه فاطمی* 2؛ سالومه دینی* 3 | ||
| 1دانشیار بیوشیمی، گروه پزشکی، دانشکده پزشکی، واحد قم، دانشگاه آزاد اسلامی، قم، ایران. | ||
| 2دانشیار بیوشیمی، پژوهشکده مواد و سوخت هسته‌ای، پژوهشگاه علوم و فنون هسته‌ای، تهران، ایران | ||
| 3پژوهشگر، باشگاه پژوهشگران و نخبگان جوان، دانشگاه آزاد اسلامی واحد کرج، کرج، ایران | ||
| چکیده | ||
| در این تحقیق، تاثیرکاربردپودر و اسانس زیره سیاه با دوز 2/0 درصد (w/w)در مهار ایجاد سرطان کولون القاء شده با دی متیل هیدرازین (DMH)بر روی تغییرات شاخص‌های بیوشیمیایی مانند آنزیم‌های کاتالاز(CAT) ،سوپر‌اکسید دیسموتاز(SOD)،گلوتاتیون احیا(GSH)، پر‌اکسیداسیون لیپید(LP)و ظرفیت آنتی اکسیدانی کل پلاسما(FRAP) و همچنین تغییرات پاتولوژیکی مورد بررسی قرار گرفتند .نتایج نشان داد که تزریقDMHباعث افزایش GSH وFRAp و کاهشSOD گردید. در حالیکهتیمار رت‌ها با اسانس و پودر زیره سیاه تاثیری بر روی بهبود پارامترهای بیوشیمیایی نداشته است، نتایج پاتولوژی تاثیر مثبت تیمارها را در روند سرطانزایی نشان دادند. لذا با توجه به نتایج بهدست آمده، فعالیت ضد سرطانی اسانس و پودر زیره سیاه، احتمالا مربوط به اثرات آن در مسیرهای دیگر متابولیکی (غیر از سیستم دفاع آنتی اکسیدانی و استرس اکسیداتیو) می باشد. | ||
| کلیدواژه‌ها | ||
| استرس اکسیداتیو؛ دی متیل هیدرازین؛ زیره سیاه؛ سرطان کولون | ||
| عنوان مقاله [English] | ||
| Effects of Carum carvi L. on Antioxidant status and oxidative stress parameters in rats exposed to 1, 2-dimethyl hydrazine | ||
| نویسندگان [English] | ||
| Aboolfazl Dadchah1؛ Faezeh Fatemi2؛ Saloomeh Dini3 | ||
| 1- Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, Iran | ||
| 2Materials and Nuclear Fuel Research School, Nuclear Science and Technology Research Institute, Tehran, Iran | ||
| 3Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran | ||
| چکیده [English] | ||
| In the current study, the effect of usage of caraway powder and its essential oils at the dose of 0.2% (w/w) were studied on colon cancer prevention induced by dimethyl hydrazine (DMH) through the estimation of biochemical parameters including catalase (CAT) and superoxide dismutase (SOD) enzymes, glutathione (GSH), lipid peroxidation (LP) and ferric reducing ability of plasma (FRAP) as well as histopathological changes. The results showed that the levels of GSH and FRAP were increased and SOD activity was decreased by DMH. Even though caraway powder and its essential oils failed to alter the tested biochemical parameters, histopathological analysis indicated improved effects in carcinogenesis. Therefore, the results demonstrated that the chemopreventive effects of the treatments were due to the other metabolic pathways than oxidative stress/antioxidant systems. | ||
| کلیدواژه‌ها [English] | ||
| Colon cancer, Carum carvi L, Oxidative stress, Dimethyl hydrazine | ||
| مراجع | ||
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