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نعمتی, فاطمه, بهنیا, سهراب. (1403). مقالۀ پژوهشی: بررسی تأثیر دمای محیط بر پدیده رونویسی ژن: نمای لیاپانوف. جلوه هنر, 14(1), 45-67. doi: 10.22051/ijap.2023.44574.1340
فاطمه نعمتی; سهراب بهنیا. "مقالۀ پژوهشی: بررسی تأثیر دمای محیط بر پدیده رونویسی ژن: نمای لیاپانوف". جلوه هنر, 14, 1, 1403, 45-67. doi: 10.22051/ijap.2023.44574.1340
نعمتی, فاطمه, بهنیا, سهراب. (1403). 'مقالۀ پژوهشی: بررسی تأثیر دمای محیط بر پدیده رونویسی ژن: نمای لیاپانوف', جلوه هنر, 14(1), pp. 45-67. doi: 10.22051/ijap.2023.44574.1340
نعمتی, فاطمه, بهنیا, سهراب. مقالۀ پژوهشی: بررسی تأثیر دمای محیط بر پدیده رونویسی ژن: نمای لیاپانوف. جلوه هنر, 1403; 14(1): 45-67. doi: 10.22051/ijap.2023.44574.1340

مقالۀ پژوهشی: بررسی تأثیر دمای محیط بر پدیده رونویسی ژن: نمای لیاپانوف

فیزیک کاربردی ایران
دوره 14، شماره 1 - شماره پیاپی 36، فروردین 1403، صفحه 45-67    اصل مقاله (2.21 M)
نوع مقاله: مقاله پژوهشی
شناسه دیجیتال (DOI): 10.22051/ijap.2023.44574.1340
نویسندگان
فاطمه نعمتی1؛ سهراب بهنیا* 2
1دانشجوی دکتری، گروه فیزیک، دانشگاه صنعتی ارومیه، ارومیه، ایران
2استاد، گروه فیزیک، دانشگاه صنعتی ارومیه، ارومیه، ایران
چکیده
 بیان ژن به عنوان پدیده­ای شناخته می­شود که زندگی انسان را شکل می­دهد. این پدیده بسیار پیچیده، از دو مرحله رونویسی و ترجمه شکل گرفته است. با توجه به اینکه دما ساعت زمانی سیستم­های زیست­شناختی است، در مطالعه حاضر، تأثیر دمای محیط از راه ترموستات نوز- هوور در الگو‌سازی ریاضی بیان ژن انجام شده است. در کار حاضر از رویکرد نمای لیاپانوف برای بررسی اثر کمیت­های کنترل بر بیان ژن، از جمله سرعت تخریب mRNA و پروتئین‌ها، یافتن نقاط بحرانی (محدودیت‌های مرزی پدیده)، مقادیر مرزی سطح mRNA و پروتئین استفاده شده است. سرعت تخریب در فرآیند سنتز پروتئین با کمک رویکرد نمای لیاپانوف بررسی شده است. این مطالعه نشان داد که دمای 306 کلوین دارای بیشینه سطح رونویسی mRNA برای باکتری اشریشیا کلی است. همچنین از راه رویکرد آشوب تایید شد که افزایش نرخ تخریب mRNA منجر به افزایش رونویسی و در نتیجه افزایش آشوبناکی سیستم می‌شود.
کلیدواژه‌ها
رونویسی ژن؛ نمای لیاپانوف؛ طیف مولتی فرکتال؛ دمای محیط
عنوان مقاله [English]
Research Paper: Investigating the Effect of Environmental Temperature on the Phenomenon of Gene Transcription: Lyapunov Exponent
نویسندگان [English]
Fatemeh Nemati1؛ Sohrab Behnia2
1PhD Student, Department of Physics, Urmia University of Technology, Urmia, Iran
2Professor, Department of Physics, Urmia University of Technology, Urmia, Iran
چکیده [English]
Gene expression is known as a phenomenon that shapes human life. This very complex phenomenon is formed from two stages: transcription and translation. In this study, we used the Nose-Hoover thermostat to model the effect of ambient temperature on gene expression since temperature regulates the biological clock of living systems. We have used the Lyapunov exponent approach to investigate the effect of control parameters on gene expression, including the degradation rates of messenger RNA and proteins, and to find critical points (phenomenon boundary limits), mRNA, and protein level boundary values. The rate of degradation in the process of protein synthesis has been investigated with the help of the Lyapunov exponent approach. According to this study, the optimal temperature for the production of mRNA molecules by Escherichia coli bacteria is 306 Kelvin. The study also used the chaos approach to show that the faster the mRNA molecules are degraded, the more they are transcribed, and the more chaotic the system becomes.
کلیدواژه‌ها [English]
Gene Transcription, Lyapunov Exponent, Multi-fractal Spectrum, Environmental Temperature
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آمار
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